The National Institute of High Security Animal Diseases (NIHSAD) of Indian Council of Agricultural Research is a premier institute of India for research on exotic and emerging pathogens of animals. NIHSAD came into existence on 8th Aug., 2014 as an independent institute under ICAR from its original status as High Security Animal Disease Laboratory (HSADL), a regional station of Indian Veterinary Research Institute (IVRI), Izatnagar. The institute has contributed significantly by detecting many animal diseases of exotic origin and preventing them from entering our country. The bio-containment laboratory of HSADL has been operational continuously since year 1998 for handling exotic/emerging animal diseases, providing rapid diagnosis and conducting basic and applied research on emerging animal pathogens. Realizing the challenging need of stringent biological safety measures in the era of globalized animal trade and the growing threat of novel pathogens, the HSADL, as part of IVRI, was upgraded as an independent national level institute for extending better services to the nation in animal health through its mandated programmes and objectives.