New TB-resistant cows developed in China

Posted on:02 Feb 2017 09:13:57
New TB-resistant cows developed in China
02 February 2017 Current Affairs: Chinese scientists from Northwest A&F University have produced world’s first live cows with increased resistance to bovine tuberculosis (TB). This development shows that genetic modification technology can be better suited to producing transgenic livestock with purposefully manipulated genetic.

Researchers had used a modified version of the CRISPR gene-editing technology called CRISPR/Cas9n to insert a new TB resistance gene NRAMP1 into the genome of bovine foetal fibroblasts, cell derived from female dairy cows.

 These cells were then used as donor cells in a process called somatic cell nuclear transfer. In it, nucleus of a donor cell carrying the new gene was inserted into an egg cell, known as an ovum, from a female cow.

 These ovum were then nurtured in the lab into embryos and transferred into mother cows for a normal pregnancy cycle. During this cycle, cows were produced with no off target effects on the animals’ genetics — a common problem when creating transgenic animals using CRISPR.

This scientific process revealed that NRAMP1 had successfully integrated into the genetic code at the targeted region in all of the calves. 

When it was exposed to Mycobacterium bovis (M. bovis), bacterium that causes bovine TB, transgenic animals showed increased resistance to M. bovis. Further in laboratory tests, the white blood cells taken from the calves also showed much resistance to M. bovis exposure.

Monthly Current Affairs

Current Affairs Section

Daily Current Affairs Quiz

Subscribe to Current Affairs

Enter your email to get daily current affairs

Current Affairs 2018 July

18 JULY
NEWS
17 JULY
NEWS
16 JULY
NEWS
15 JULY
NEWS

Current Affairs 2018 June

30 JUNE
NEWS
29 JUNE
NEWS
28 JUNE
NEWS
27 JUNE
NEWS

Current Affairs 2018 May

31 MAY
NEWS
30 MAY
NEWS
29 MAY
NEWS
28 MAY
NEWS