December 2016 Current Affairs

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Endosulfan causes DNA damage in animals : Study

Endosulfan causes DNA damage in animals : Study
09 August 2016 Current Affairs: Researchers in India for the first time have found that mice and rats exposed to endosulphan suffer from DNA damage and genomic instability, and impaired DNA damage response. This breakthrough discovery was discovered team of researchers led by Prof. Sathees Raghavan from the Bengaluru based IISc (Department of Biochemistry).

Highlights of Research  : When animals get exposed endosulphan, it generates reactive oxygen species in their body which is a potent DNA damaging agent. These reactive oxygen species in turn cause DNA damage in the form of breaks in DNA strands. These broken DNA strands generally tend to repair themselves by rejoining. 

But Endosulfan further causes extensive processing of broken DNA leading to increased and long deletion in the strands. Endosulfan also increases the damage by altering DNA repair levels by promoting erroneous repair of the broken DNA strands. Erroneous repair by rejoining would lead to undesirable genome level changes that may further lead to genomic instability causing cancer and other genetic abnormalities. 

Non-homologous end joining (NHEJ) of the broken ends of broken DNA strands is one of the major mechanism. However, in animals exposed to Endosulfan, micro homology mediated end joining (MMEJ) is seen which is enhanced activity of an error-prone and harmful repair mechanism.

Endosulfan :  Endosulfan is an organ chlorine pesticide that induces breaks in DNA strands and disturbs the damage response mechanism found in cells thus leading to compromised DNA strand repair. If people who have occupational exposure (mostly related to agriculture) of 2-70 microgram/litre of Endosulfan in blood then genetic abnormality and increased cancer occurrences have been witnessed in them. In case of environment, open spraying of Endosulfan causes a disaster on the biodiversity of the area. It leads to decline in plant diversity particularly for native species. Fishes are worst hit.


December 2016 Current affairs

November 2016 Current affairs
30 NOV
NEWS
29 NOV
NEWS
28 NOV
NEWS
26 NOV
NEWS
25 NOV
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24 NOV
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October 2016 Current affairs
31 OCT
NEWS
27 OCT
NEWS
26 OCT
NEWS
25 OCT
NEWS
24 OCT
NEWS
22 OCT
NEWS

September 2016 Current affairs
30 SEP
NEWS
29 SEP
NEWS
28 SEP
NEWS
27 SEP
NEWS
26 SEP
NEWS
24 SEP
NEWS

August 2016 Current affairs
31 AUG
NEWS
30 AUG
NEWS
29 AUG
NEWS
27 AUG
NEWS
26 AUG
NEWS
25 AUG
NEWS



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